BDBM50441651 CHEMBL2437417

SMILES Nc1cc(CN2CCC(CC2)C(=O)N2CCC(CC2)n2c3ccccc3n(CCCC(F)(F)F)c2=O)ccn1

InChI Key InChIKey=JVNKPOHWBICHOM-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50441651   

TargetHistamine H3 receptor(Guinea pig)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441651(CHEMBL2437417)
Affinity DataKd:  7.90nMAssay Description:Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441651(CHEMBL2437417)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441651(CHEMBL2437417)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed