BDBM50441643 CHEMBL2437424

SMILES CC(C)Cn1c2cc(F)ccc2n(C2CCN(CC2)C(=O)C2CCN(Cc3ccnc(N)c3)CC2)c1=O

InChI Key InChIKey=TXRQOKKFUWBRKJ-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50441643   

TargetHistamine H3 receptor(Guinea pig)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441643(CHEMBL2437424)
Affinity DataKd:  2.5nMAssay Description:Antagonist activity at histamine H3 receptor in electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441643(CHEMBL2437424)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441643(CHEMBL2437424)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed