BDBM50441363 CHEMBL2332280

SMILES [#6](\[#6]=[#6](\c1ccccc1)-c1ccccc1)-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1

InChI Key InChIKey=GFZPTQHNFIWYND-UHFFFAOYSA-N

Data  2 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50441363   

TargetMuscarinic acetylcholine receptor M2(Rat)
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50: 372nMAssay Description:Antagonist activity at rat muscarinic M2 receptor isolated from brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Targacept

Curated by ChEMBL
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50: 76nMAssay Description:Antagonist activity at rat muscarinic M1 receptor isolated from brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50: 380nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50: 380nMAssay Description:Non-competitive antagonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of nicotine-induced calcium influx incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataIC50: 100nMAssay Description:Inhibition of human alpha3beta4 nAChR expressed in CHO cells assessed as inhibition of calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium influx by calcium-4 based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]nicotine from human alpha4beta2 nAChR expressed in human SH-EP1 cell membranes after 2 hrs by liquid scintillation counting analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50441363(CHEMBL2332280)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed