BDBM50441290 CHEMBL2431503

SMILES CCOC(=O)c1c(O)csc1Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=SXQPDHVASUORMK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50441290   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
State Key Laboratory of Bioreactor Engineering

Curated by ChEMBL
LigandPNGBDBM50441290(CHEMBL2431503)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal His10-tagged human DHODH (Met30 to Arg396) expressed in Escherichia coli BL21 (DE3) using dihydroorotate as substrate measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
State Key Laboratory of Bioreactor Engineering

Curated by ChEMBL
LigandPNGBDBM50441290(CHEMBL2431503)
Affinity DataIC50: 367nMAssay Description:Inhibition of Plasmodium falciparum DHODH (Phe158 to Ser569) expressed in Escherichia coli BL21 using dihydroorotate as substrate measured every 30 s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed