BDBM50440531 CHEMBL2426168

SMILES Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C(F)(F)F

InChI Key InChIKey=WMCOYUSJXXCHFH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50440531   

TargetRecQ-like DNA helicase BLM(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of BLM helicase (unknown origin) binding to DNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetRecQ-like DNA helicase BLM(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of BLM helicase (unknown origin) assessed as branch migration activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of WRN helicase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetRecQ-like DNA helicase BLM(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of BLM (unknown origin) by gel-based DNA unwinding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of WRN (unknown origin) by gel-based DNA unwinding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetATP-dependent DNA helicase Q1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of RECQ1 (unknown origin) by gel-based DNA unwinding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetRecQ-like DNA helicase BLM(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 3.48E+4nMAssay Description:Inhibition of 5'-biotin labeled duplex forked-DNA binding to BLM (unknown origin) assessed as increase in unbound DNA levels after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetRecQ-like DNA helicase BLM(Human)
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of His-tagged BLM (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in BLM helicase unwinding activity using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed