BDBM50440368 CHEMBL2425146

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(cc1)-n1ccnc1)C(C)(C)C

InChI Key InChIKey=UFUDJJBHRBMKDD-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50440368   

TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataIC50: 800nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAK in human HT-29 cells assessed as Tyr397 phosphorylation after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of FAK (unknown origin) using biotinylated-His-TEVhsFAK(31-686)(K454R) as substrate after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50440368(CHEMBL2425146)
Affinity DataKd:  1.53E+3nMAssay Description:Binding affinity to FAK kinase (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed