BDBM50440242 CHEMBL2426663

SMILES CC(C)([C@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(=O)Nc1nncs1

InChI Key InChIKey=XFFATDFCPKLQRT-UHFFFAOYSA-N

Data  4 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50440242   

TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataEC50:  23nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataEC50: >5.00E+6nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataEC50:  92nMAssay Description:Agonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-induced AP-1 activation by luciferase reporter gene ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataKi:  6.70nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataKi:  18nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataKi:  56nMAssay Description:Binding affinity to progesterone receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50440242(CHEMBL2426663)
Affinity DataKi: >2.50E+4nMAssay Description:Binding affinity to androgen receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed