BDBM50439467 CHEMBL2417685

SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc3ccccc3)c2c1

InChI Key InChIKey=NAQYYLDGRRJWKO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50439467   

TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50439467(CHEMBL2417685)
Affinity DataIC50: 2.94E+4nMAssay Description:Inhibition of human recombinant His-tagged SIRT3 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50439467(CHEMBL2417685)
Affinity DataIC50: 2.58E+4nMAssay Description:Inhibition of human recombinant GST-tagged SIRT2 using KI179 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50439467(CHEMBL2417685)
Affinity DataIC50: 5.98E+3nMAssay Description:Inhibition of human recombinant GST-tagged SIRT1 using KI177 as substrate preincubated for 5 mins followed by enzyme addition measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed