BDBM50439157 CHEMBL2418752

SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cnn(Cc4cccc(F)c4)c3)c2c1

InChI Key InChIKey=WXMICXPDNXUCTC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50439157   

TargetALK tyrosine kinase receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50439157(CHEMBL2418752)
Affinity DataIC50: 139nMAssay Description:Inhibition of ALK in human KARPAS299 cells assessed as phosphorylated Stat3 level after 6 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50439157(CHEMBL2418752)
Affinity DataIC50: 220nMAssay Description:Inhibition of ALK in human KARPAS299 cells assessed as phosphorylated ALK level after 6 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Aurigene Discovery Technologies

Curated by ChEMBL
LigandPNGBDBM50439157(CHEMBL2418752)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of wild type human recombinant ALK after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed