BDBM50438822 CHEMBL2413367

SMILES COc1ccc(C[C@@H]2N(CCc3cc(OC)c(OC)cc23)[C@@H](C(=O)NC(C)C)c2ccccc2)cc1OC

InChI Key InChIKey=HXHOBPVRRPCTLG-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50438822   

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataIC50: 417nMAssay Description:Binding affinity to orexin receptor 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataIC50: 6nMAssay Description:Binding affinity to orexin receptor 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at orexin-1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataIC50: 417nMAssay Description:Antagonist activity at orexin-2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataIC50: 417nMAssay Description:Antagonist activity at OX2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at OX1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataKi:  6nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataKi:  417nMAssay Description:Displacement of (2S)-N-(2-pyrrol-1-ylphenyl)-1-[2-[1-(tritritiomethyl)benzimidazol-2-yl]sulfanylacetyl]pyrrolidine-2-carboxamide from human OX2 recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50438822(CHEMBL2413367)
Affinity DataKi:  417nMAssay Description:Binding affinity to human OX2RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed