BDBM50438233 CHEMBL2407988

SMILES COc1cc(CN2CCN(CC2)c2ccc(cc2C)C(=O)NC2CC2)cc2NC(=O)C(C)Oc12

InChI Key InChIKey=YNLLQEVBYODKND-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50438233   

TargetPoly [ADP-ribose] polymerase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438233(CHEMBL2407988)
Affinity DataEC50:  7.70E+4nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438233(CHEMBL2407988)
Affinity DataIC50: 147nMAssay Description:Inhibition of human PARP1 catalytic activity after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438233(CHEMBL2407988)
Affinity DataEC50:  20nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed