BDBM50438149 CHEMBL2409885

SMILES COc1cccc(c1)-c1csc(Nc2ccc(CCN3CC[C@H](O)C[C@@H]3CO)cc2)n1

InChI Key InChIKey=OAMJOAOECFYPCZ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50438149   

TargetSphingosine kinase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438149(CHEMBL2409885)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of purified human SphK2 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438149(CHEMBL2409885)
Affinity DataEC50:  870nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50438149(CHEMBL2409885)
Affinity DataIC50: 50nMAssay Description:Inhibition of purified human SphK1 assessed as inhibition of formation of [33P]-S1P after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed