BDBM50437878 CHEMBL2407929

SMILES Cc1cc(ccn1)C(C[C@@H](c1ccc(cc1)-c1ccc(cc1)C(O)=O)c1ccccc1C)N=O

InChI Key InChIKey=GEMWXWUPINNETM-UHFFFAOYSA-N

Data  1 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50437878   

TargetG-protein coupled bile acid receptor 1(Mouse)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50437878(CHEMBL2407929)
Affinity DataEC50:  190nMAssay Description:Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50437878(CHEMBL2407929)
Affinity DataEC50:  580nMAssay Description:Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50437878(CHEMBL2407929)
Affinity DataEC50:  20nMAssay Description:Agonist activity at recombinant human GPBAR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50437878(CHEMBL2407929)
Affinity DataEC50:  57nMAssay Description:Agonist activity at recombinant human GPBAR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50437878(CHEMBL2407929)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Mouse)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50437878(CHEMBL2407929)
Affinity DataEC50:  93nMAssay Description:Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50437878(CHEMBL2407929)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed