BDBM50437216 CHEMBL2402573

SMILES CC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NCC[C@@H](CO)O)c2cccc(c2)Cl)(C#N)c3ccc(cc3)Cl

InChI Key InChIKey=ZSZGGSIFAMXPIG-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50437216   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50437216(CHEMBL2402573)
Affinity DataIC50: 196nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50437216(CHEMBL2402573)
Affinity DataIC50: 9nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProtein Mdm4(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50437216(CHEMBL2402573)
Affinity DataIC50: 580nMAssay Description:Inhibition of MDM4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed