BDBM50437161 CHEMBL2401832

SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl

InChI Key InChIKey=LVYXERPKYAQGKM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50437161   

TargetAurora kinase B(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 600nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 500nMAssay Description:Inhibition of ALK autophosphorylation in human Karpas-299 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 200nMAssay Description:Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 42nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 40nMAssay Description:Inhibition of ALK (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 25nMAssay Description:Inhibition of RON (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 11nMAssay Description:Inhibition of aurora-B (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 in presence of mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437161(CHEMBL2401832)
Affinity DataIC50: 26nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed