BDBM50436855 CHEMBL2403842::US8592432, 1

SMILES CC(C)Oc1cc(C2CCN(CC2)C(=O)CN(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

InChI Key InChIKey=ADAQBVKANMBBGO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50436855   

TargetALK tyrosine kinase receptor(Human)
TBA

US Patent
LigandPNGBDBM50436855(CHEMBL2403842 | US8592432, 1)
Affinity DataIC50: 26nMAssay Description:The inhibition of ALK tyrosine kinase activity may be demonstrated using known methods, for example using the recombinant kinase domain of the ALK in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2014
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
TBA

US Patent
LigandPNGBDBM50436855(CHEMBL2403842 | US8592432, 1)
Affinity DataIC50: 26nMAssay Description:Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50436855(CHEMBL2403842 | US8592432, 1)
Affinity DataIC50: 416nMAssay Description:Inhibition of TEL-fused insulin receptor (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed