BDBM50436423 CHEMBL2397014

SMILES COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1

InChI Key InChIKey=XXHHOTZUJIXPJX-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50436423   

LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 7nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataEC50:  4nMAssay Description:Inhibition of LRRK2 G2019S mutant-induced neuronal toxicity in human cortical neuronsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant wild type LRRK2 using biotin-LRRKtide as substrate preincubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human LRRK2 measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human LRRK2 G2019S mutant measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed