BDBM50436085 CHEMBL2397093::US10273214, Example 1180-15

SMILES COc1ccc(OC[C@H]2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(Cl)c2)cc1

InChI Key InChIKey=VYMILMYEENZHAR-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50436085   

TargetGlutamate receptor ionotropic, NMDA 1/2D(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436085(CHEMBL2397093 | US10273214, Example 1180-15)
Affinity DataEC50:  8.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2C(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436085(CHEMBL2397093 | US10273214, Example 1180-15)
Affinity DataEC50:  9.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Human)
Emory University

US Patent
LigandPNGBDBM50436085(CHEMBL2397093 | US10273214, Example 1180-15)
Affinity DataIC50: 2.40E+3nMAssay Description:The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 2D(Human)
Emory University

US Patent
LigandPNGBDBM50436085(CHEMBL2397093 | US10273214, Example 1180-15)
Affinity DataIC50: 4.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent