BDBM50436074 CHEMBL2397209::US10273214, Example 1180-11

SMILES COc1ccc(OCC2N(CCc3cc(OC)c(OC)cc23)C(=O)c2cccc(I)c2)cc1

InChI Key InChIKey=ZESJCUWDBRLAQK-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50436074   

TargetGlutamate receptor ionotropic, NMDA 1/2C(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436074(CHEMBL2397209 | US10273214, Example 1180-11)
Affinity DataEC50:  4.00E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2C receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Rat)
Emory University

Curated by ChEMBL
LigandPNGBDBM50436074(CHEMBL2397209 | US10273214, Example 1180-11)
Affinity DataEC50:  4.90E+3nMAssay Description:Activity at rat recombinant GluN1/GluN2D receptor assessed as potentiation of glycine/glutamate-induced activation by two-electrode voltage clamp tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Human)
Emory University

US Patent
LigandPNGBDBM50436074(CHEMBL2397209 | US10273214, Example 1180-11)
Affinity DataIC50: 3.10E+4nMAssay Description:The assay involves using a cell line that expresses the NR1 subunit together with either NR2C or NR2D. These cell lines can be prepared by transfecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent