BDBM50435763 CHEMBL2392711

SMILES CNc1nc(nc(n1)N1CCN(C)CC1)N1CCC(CC1)C(=O)NCc1ccccc1C(F)(F)F

InChI Key InChIKey=JXPKVUBSJSCTLI-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50435763   

TargetBifunctional epoxide hydrolase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 40nMAssay Description:Inhibition of human soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 11nMAssay Description:Inhibition of human sEH using EnzChek as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured every 30 secs for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50435763(CHEMBL2392711)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed