BDBM50434287 CHEMBL2386346

SMILES CCOc1cc(ccc1C2=N[C@@]([C@@](N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)c4ccc(cc4)Cl)(C)c5ccc(cc5)Cl)C(C)(C)C

InChI Key InChIKey=QBGKPEROWUKSBK-UHFFFAOYSA-N

Data  4 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50434287   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataIC50: 18nMAssay Description:Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to human MDM2 by by Surface Plasmon Resonace (SPR) spectroscopy binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataIC50: 18nMAssay Description:Inhibition of N-terminal human recombinant MDM2 assessed as inhibition of protein interaction with p53 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataIC50: 18nMAssay Description:Inhibition of MDM2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant human GST-tagged HDM2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataIC50: 18nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed