BDBM50433706 CHEMBL2381135::US9290487, compound of Ex. 37

SMILES COc1cc(F)c(F)cc1-c1ccc(OCc2cccc(c2)C(=O)N2CCC[C@H]2C(O)=O)cc1

InChI Key InChIKey=DMZAQSNZHAMCAT-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50433706   

TargetGlycogen [starch] synthase, muscle(Human)
Ajinomoto

US Patent
LigandPNGBDBM50433706(CHEMBL2381135 | US9290487, compound of Ex. 37)
Affinity DataEC50:  10nMpH: 7.3 T: 2°CAssay Description:To a polystyrene 96-well plate, a solution containing 30 mM glycylglycine (pH 7.3), 40 mM KCl, 20 mM MgCl2, 9.2% DMSO containing one of the test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
Go to US Patent

TargetGlycogen [starch] synthase, muscle(Human)
Ajinomoto

US Patent
LigandPNGBDBM50433706(CHEMBL2381135 | US9290487, compound of Ex. 37)
Affinity DataEC50:  140nMAssay Description:Activation of human recombinant muscle GYS1 expressed in insect sf9 cells using glycogen and UDP-glucose as substrates by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed