BDBM50433441 PARTHENOLIDE

SMILES C\C1=C/CC[C@@]2(C)O[C@H]2[C@H]2OC(=O)C(=C)[C@@H]2CC1

InChI Key InChIKey=KTEXNACQROZXEV-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50433441   

TargetNitric oxide synthase, inducible(Mouse)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50433441(PARTHENOLIDE)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of iNOS in mouse RAW264.7 cells assessed as LPS-induced nitric oxide production treated for 30 mins followed by LPS challenge measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetTranscriptional activator Myb(Chicken)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50433441(PARTHENOLIDE)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of c-Myb-induced mim-1 gene expression in doxycyclin-treated chicken HD11 cells after 24 hrs by GFP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTranscriptional activator Myb(Chicken)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50433441(PARTHENOLIDE)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of c-Myb-induced mim-1 gene expression in doxycyclin-treated chicken HD11 cells after 24 hrs by GFP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTranscription factor Sp1(Human)TBA
LigandPNGBDBM50433441(PARTHENOLIDE)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibition of Sp1 (unknown origin) by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetNitric oxide synthase, inducible(Mouse)
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50433441(PARTHENOLIDE)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of iNOS in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of LPS-induced nitrite production incubated for 30 min prior to LPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetCaspase-1(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50433441(PARTHENOLIDE)
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of caspase 1 (unknown origin) using N-acetyl-Tyr-Val-Ala-Asp-para-nitroanilide substrate assessed as rate of para-nitroanilide release by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed