BDBM50433369 CHEMBL2377825

SMILES c1ccc(c(c1)C(=O)c2c(nc(s2)Nc3ccc(cc3)S(=O)(=O)N)N)[N+](=O)[O-]

InChI Key InChIKey=JXJHPQHLHQTQQI-UHFFFAOYSA-N

Data  9 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50433369   

TargetCyclin-K(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 13nMAssay Description:Inhibition of CDK9/Cyclin K (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of CDK5/P25 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 38nMAssay Description:Inhibition of CDK3/Cyclin E (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of CDK1/Cyclin A (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of GST-tagged CDK1/cyclin B1 (unknown origin) expressed in baculovirus expression system using histone H1 as substrate measured after 45 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged CDK4/Cyclin D1 (unknown origin) expressed in baculovirus expression system using GST-pRb (776 to 928 residues) as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of South Australia Cancer Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of GST-tagged CDK2/Cyclin E (unknown origin) expressed in baculovirus expression system using GST-pRb (776 to 928 residues) as substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)