BDBM50432896 CHEMBL2376842

SMILES CN(C1CCCCC1)C(=O)n1nnc(Cc2ccc(cc2)-c2ccccc2)n1

InChI Key InChIKey=LLRSVFMJVIEWCG-UHFFFAOYSA-N

Data  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50432896   

TargetTransient receptor potential cation channel subfamily A member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50432896(CHEMBL2376842)
Affinity DataEC50:  150nMAssay Description:Agonist activity at GDH-tagged human TRPA1 receptor expressed in HEK293F cells assessed as increase in intracellular Ca2+ concentration by FLIPR assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50432896(CHEMBL2376842)
Affinity DataIC50: 96nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as [14C]AEA hydrolysis to [14C]Ethanolamine after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50432896(CHEMBL2376842)
Affinity DataEC50:  150nMAssay Description:Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50432896(CHEMBL2376842)
Affinity DataIC50: 1.54E+4nMAssay Description:Antagonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ elevati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50432896(CHEMBL2376842)
Affinity DataIC50: 9.20E+3nMAssay Description:Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ elevation incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50432896(CHEMBL2376842)
Affinity DataEC50:  250nMAssay Description:Agonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50432896(CHEMBL2376842)
Affinity DataIC50: 602nMAssay Description:Inhibition of MAGL (unknown origin) expressed in African green monkey COS7 cell cytosolic fraction assessed as [3H]2-AG hydrolysis to [3H]arachidonic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed