BDBM50431519 CHEMBL2348862

SMILES CC(C)(O)c1ccc(cn1)-c1cnc2NC(=O)CN(CC3CCOCC3)c2n1

InChI Key InChIKey=UWUPKVZQISLSSA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50431519   

LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetFKBP12A/mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 390nMAssay Description:Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 106nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 106nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using GST-p70S6 as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 315nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 106nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50431519(CHEMBL2348862)
Affinity DataIC50: 386nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed