BDBM50430875 CHEMBL2336005::US9062066, LCB 03-0110

SMILES Oc1cccc(Nc2ccnc3cc(sc23)-c2cccc(CN3CCOCC3)c2)c1

InChI Key InChIKey=ZCWXCBKGPJOAFQ-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50430875   

TargetTyrosine-protein kinase SYK(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 25.2nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
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TargetEpithelial discoidin domain-containing receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 164nMAssay Description:Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR1 expressed in HEK293 cells by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 171nMAssay Description:Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR2 expressed in HEK293 cells by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant activated DDR2 tyrosine kinase domain (unknown origin) using histone H2B peptide substrate and [32P]ATP incubated for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 145nMAssay Description:Inhibition of recombinant non-activated DDR2 tyrosine kinase domain (unknown origin) using histone H2B peptide substrate and [32P]ATP incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 164nMAssay Description:Inhibition of human DDR1b expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 171nMAssay Description:Inhibition of human DDR2 expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 26.1nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetEphrin type-A receptor 3(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 5.10nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 4.60nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 1.30nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 17.7nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase HCK(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 50.7nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase HCK(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 4.40nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fgr(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 3.70nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Yes(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 2.10nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lyn(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 2.30nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lyn(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 4.30nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM50430875(CHEMBL2336005 | US9062066, LCB 03-0110)
Affinity DataIC50: 21.6nMpH: 8.0Assay Description:The inhibitory activity measurement against the kinases mentioned above was measured in the kinase inhibition reaction mixture containing 2 ul purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent