BDBM50429775 CHEMBL2336353::N-(2-Hydroxyphenyl)Cinnamamide

SMILES Oc1ccccc1NC(=O)\C=C\c1ccccc1

InChI Key InChIKey=CYJJBQPBDGQQFZ-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50429775   

Target72 kDa type IV collagenase(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429775(N-(2-Hydroxyphenyl)Cinnamamide | CHEMBL2336353)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429775(N-(2-Hydroxyphenyl)Cinnamamide | CHEMBL2336353)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429775(N-(2-Hydroxyphenyl)Cinnamamide | CHEMBL2336353)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetShiga toxin subunit A(Shigella dysenteriae)
TBA

Curated by ChEMBL
LigandPNGBDBM50429775(N-(2-Hydroxyphenyl)Cinnamamide | CHEMBL2336353)
Affinity DataKi:  1.87E+4nMAssay Description:Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed