BDBM50428976 CHEMBL2333219

SMILES COc1ccc(CNc2c(CO)cnc3c(cc(cc23)C#N)C2CC2)cc1Cl

InChI Key InChIKey=FGBIHGKWPVSHSO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50428976   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428976(CHEMBL2333219)
Affinity DataIC50: 0.277nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428976(CHEMBL2333219)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE2 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428976(CHEMBL2333219)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Indian Institute of Technology (B.H.U.)

Curated by ChEMBL
LigandPNGBDBM50428976(CHEMBL2333219)
Affinity DataIC50: 339nMAssay Description:Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50428976(CHEMBL2333219)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant PDE5A1 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed