BDBM50428825 CHEMBL1473252::tanshinone IIA sulfonate

SMILES Cc1c2c(oc1S([O-])(=O)=O)-c1ccc3c(CCCC3(C)C)c1C(=O)C2=O

InChI Key InChIKey=UJCACMLMPLLRGW-UHFFFAOYSA-M

Data  5 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50428825   

TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50428825(tanshinone IIA sulfonate | CHEMBL1473252)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of 6xHis-tagged SARS-CoV-2 papain-like protease expressed in Escherichia coli BL21 (DE3) using ISG15-FITC as substrate incubated for 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50428825(tanshinone IIA sulfonate | CHEMBL1473252)
Affinity DataKd:  6.10E+4nMAssay Description:Binding affinity to biotin-tagged SARS-CoV-2 papain-like protease expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details Article
PubMed
TargetCocaine esterase(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50428825(tanshinone IIA sulfonate | CHEMBL1473252)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50428825(tanshinone IIA sulfonate | CHEMBL1473252)
Affinity DataKi:  2.88E+4nMAssay Description:Inhibition of human iCE using CPT-11 as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50428825(tanshinone IIA sulfonate | CHEMBL1473252)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human BChE using butyrylthiocholine as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50428825(tanshinone IIA sulfonate | CHEMBL1473252)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human AChE using acetylthiocholine as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50428825(tanshinone IIA sulfonate | CHEMBL1473252)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed