BDBM50428400 CA inhibitor, 2::CHEMBL182659::[(4-Methylphenyl)Sulfonyl]Phenylamine

SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1

InChI Key InChIKey=VLVCWODDMDGANW-UHFFFAOYSA-N

Data  9 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50428400   

TargetIntestinal-type alkaline phosphatase(Bovine)
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 9.15E+3nMAssay Description:Inhibition of calf intestinal alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 2.10E+5nMAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 1.43E+4nMAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 6(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 1.34E+4nMAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 180nMAssay Description:Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CA-2 (unknown origin) after 15 mins by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 8.44E+3nMAssay Description:Inhibition of CA-12 (unknown origin) after 15 mins by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 90nMAssay Description:Inhibition of CA-9 (unknown origin) after 15 mins by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CA-1 (unknown origin) after 15 mins by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bovine)
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  70nMAssay Description:Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  395nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  395nM ΔG°:  -8.73kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  419nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  419nM ΔG°:  -8.69kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 3(Bovine)
Ondokuz Mayis University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  1.31E+4nMpH: 7.4Assay Description:The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 6(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  1.35E+4nMpH: 7.4Assay Description:The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  1.43E+4nMpH: 7.4Assay Description:The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Ataturk University

LigandPNGBDBM50428400([(4-Methylphenyl)Sulfonyl]Phenylamine | CHEMBL1826...)
Affinity DataKi:  2.11E+5nMpH: 7.4Assay Description:The CA activity was assayed by following the change in absorbance at 348 nm of 4-NPA to 4-nitrophenylate ion over a period of 3 min at 25°C using a s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed