BDBM504284 (6S)-3-[2,6-Difluoro-4-[2-(3-pyridyl)ethynyl]phenyl]-1-methyl-spiro[hexahydropyrimidine-6,4′-isochromane]-2,4-dione::US11034699, Example 10

SMILES CN1C(=O)N(C(=O)C[C@]11COCc2ccccc12)c1c(F)cc(cc1F)C#Cc1cccnc1

InChI Key InChIKey=APMCYLNNKFINAI-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504284   

TargetMetabotropic glutamate receptor 4(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM504284((6S)-3-[2,6-Difluoro-4-[2-(3-pyridyl)ethynyl]pheny...)
Affinity DataEC50:  43nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent