BDBM50428027 CHEMBL1257090

SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O

InChI Key InChIKey=RHUJMHOIQBDFQR-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50428027   

TargetProtein-serine O-palmitoleoyltransferase porcupine(Mouse)
The University of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50428027(CHEMBL1257090)
Affinity DataEC50:  25nMAssay Description:Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428027(CHEMBL1257090)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428027(CHEMBL1257090)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of full-length rat GST-tagged CK1delta using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428027(CHEMBL1257090)
Affinity DataIC50: 7.07E+3nMAssay Description:Inhibition of human recombinant CK1epsilon using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Rat)
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428027(CHEMBL1257090)
Affinity DataIC50: 140nMAssay Description:Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed