BDBM50427228 CHEMBL2325087

SMILES NC(=S)N1N=C(CC1c1ccc2ccccc2c1)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=PMNCGPKTYMEYRZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50427228   

TargetReceptor tyrosine-protein kinase erbB-3(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427228(CHEMBL2325087)
Affinity DataIC50: 5.17E+4nMAssay Description:Inhibition of human recombinant HER-3 cytoplasmic domain (665 to 1339) autophosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427228(CHEMBL2325087)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human-recombinant full-length FAK after 4 hrs by kinase-Glo-luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427228(CHEMBL2325087)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using gastrin as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427228(CHEMBL2325087)
Affinity DataIC50: 880nMAssay Description:Inhibition of human recombinant HER-2 cytoplasmic domain (676 to 1245) autophosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427228(CHEMBL2325087)
Affinity DataIC50: 660nMAssay Description:Inhibition of recombinant EGFR cytoplasmic domain (645 to 1186) (unknown origin) autophosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed