BDBM50426736 CHEMBL2322139

SMILES FC(F)(F)c1nc2cnc3[nH]ccc3c2n1C1CCCCC1

InChI Key InChIKey=DAEHEXHIXLMIJT-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50426736   

TargetTyrosine-protein kinase JAK1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426736(CHEMBL2322139)
Affinity DataEC50:  970nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426736(CHEMBL2322139)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426736(CHEMBL2322139)
Affinity DataIC50: 1.14E+4nMAssay Description:Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426736(CHEMBL2322139)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426736(CHEMBL2322139)
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426736(CHEMBL2322139)
Affinity DataIC50: 720nMAssay Description:Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50426736(CHEMBL2322139)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed