BDBM50426599 CHEMBL2325898

SMILES O=C(N[C@H](C1CC1)C(=O)N1CC[C@@H](C1)C#N)c1c[nH]c2ncc(nc12)C1CC1

InChI Key InChIKey=WRLLXWRAXRGFBQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50426599   

TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 321nMAssay Description:Inhibition of JAK2 in human PBMC expressing CD14 assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of JAK1 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JAK2 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of JAK3 (unknown origin)-mediated phosphorylation of Biotin-KAIETDKEYYTVKD incubated for 10 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426599(CHEMBL2325898)
Affinity DataIC50: 850nMAssay Description:Inhibition of JAK2 in C57BL/6 mouse whole blood assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed