BDBM50426573 CHEMBL2324349::US9434711, 306

SMILES Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O

InChI Key InChIKey=PIHSZIXJTORHOL-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50426573   

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 0.800nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 5nMT: 2°CAssay Description:For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily M member 8(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 4nMT: 2°CAssay Description:For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 1.10nMAssay Description:For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetTransient receptor potential M8 protein(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 2.30nMAssay Description:For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily M member 8(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 4nMAssay Description:Inhibition of TRPM8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 4nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells incubated for 24 hrs by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells measured after 24 hrs of menthol activation by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50: 2.30nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells measured after 24 hrs of cold activation by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed