BDBM50425862 CHEMBL2312654

SMILES CN(C)C1CCC(CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cc(C)no1

InChI Key InChIKey=ZTSOUDMNSOYCTG-UHFFFAOYSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50425862   

LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKK-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetP-selectin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 810nMAssay Description:Inhibition of ABL (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of Aurora-A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 950nMAssay Description:Inhibition of BTK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.88E+3nMAssay Description:Inhibition of CAMK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 7.97E+3nMAssay Description:Inhibition of CHK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 110nMAssay Description:Inhibition of CK1-delta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of CLK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of ECK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 590nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 7.74E+3nMAssay Description:Inhibition of GSK3-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 6.18E+3nMAssay Description:Inhibition of INSR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 220nMAssay Description:Inhibition of LCK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 160nMAssay Description:Inhibition of MAP3K9 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 18nMAssay Description:Inhibition of MAP4K4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase MARK1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of MARK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 26(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of MASK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 470nMAssay Description:Inhibition of MST2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of MYLK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of NEK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed