BDBM50425830 CHEMBL2312303

SMILES Clc1ccc(Cl)c(CNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)c1

InChI Key InChIKey=VDKBGBCLPKTOGS-UHFFFAOYSA-N

Data  32 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50425830   

TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 4.29E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCasein kinase I isoform delta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 355nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetP-selectin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 360nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPeripheral plasma membrane protein CASK(Human)
Goethe University Frankfurt Am Main

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataKd:  140nMAssay Description:Binding affinity to recombinant N-terminal His-tagged CASK (1 to 337 residues) (unknown origin) expressed in Escherichia coli assessed as dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKCzeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SGK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TAO3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of TAOK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 9.79E+3nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of VEGFR2/FLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 5.07E+3nMAssay Description:Inhibition of HGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of Mer (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50425830(CHEMBL2312303)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed