BDBM50425728 CHEMBL2365533

SMILES C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2C[C@H]3CCCN3C[C@H]2C(=O)N[C@@H]4CCOc5c4cccc5)NC

InChI Key InChIKey=GIAUJOMDUOPYLU-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50425728   

TargetE3 ubiquitin-protein ligase XIAP(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50425728(CHEMBL2365533)
Affinity DataIC50: 240nMAssay Description:Displacement of biotinyl-Smac from N-terminal His-tagged human recombinant XIAP BIR3 domain (252-356) after overnight incubation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50425728(CHEMBL2365533)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant N-terminal His-tagged XIAP BIR3 domain (252 to 356) using AVPIAQ-K(biotin)-NH2 as substrate after overnight incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50425728(CHEMBL2365533)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant His-tagged cIAP1 protein BIR3 domain (250 to 350 amino acid residues) using biotinylated-Smac as substrate after over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50425728(CHEMBL2365533)
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant N-terminal His-tagged XIAP protein BIR3 domain (252 to 356 amino acid residues) using biotinylated-Smac as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed