BDBM50425313 CHEMBL2315853

SMILES Clc1ccc2oc(nc2c1)N1CCC(CC1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccccc1

InChI Key InChIKey=ADUCABZHOQVMAT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50425313   

TargetProstaglandin G/H synthase 2(Dog)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of COX2 in dog whole blood assessed as LPS-induced PGE2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 934nMAssay Description:Inhibition of COX2 in human whole blood assessed as LPS-induced PGE2 production incubated 15 mins prior to LPS challenge measured after 24 hrs by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of COX2 in rat synovial fibroblast assessed as inhibition of IL-1-mediated PGE2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX2 in human fetal fibroblast assessed as SnCl2-induced PGF2alpha production after 40 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PGDSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 7.56E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as PGE2 level incubated for 15 mins prior to substrate addition measured after 10 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 35nMAssay Description:Inhibition of COX2 in human fetal fibroblast assessed as inhibition of IL-1beta-mediated PGE2 production after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant mPGES-1 using PGH2 as substrate incubated 20 mins prior to substrate addition measured after 30 secs by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425313(CHEMBL2315853)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of mPGES-1-mediated PGE2 production in LPS-stimulated healthy human whole blood after 20 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed