BDBM50425088 CHEMBL375623::US9402842, 54

SMILES COc1ccc-2c(c1)C(=O)c1c-2n(CCCN)c(=O)c2cc(ccc12)[N+]([O-])=O

InChI Key InChIKey=VGSWLEUZIXJPTF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50425088   

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50425088(CHEMBL375623 | US9402842, 54)
Affinity DataIC50: 1.10E+4nMpH: 7.5 T: 2°CAssay Description:A 5′-[32P]-labeled single-stranded DNA oligonucleotide containing a 3′-phosphotyrosine (N14Y) was generated as described by Dexheimer et ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

TargetTyrosyl-DNA phosphodiesterase 1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50425088(CHEMBL375623 | US9402842, 54)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant TDP1 assessed as hydrolysis of N14Y to N14P after 15 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM50425088(CHEMBL375623 | US9402842, 54)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant Tdp1 (unknown origin) using 5'-[32P]-labeled single-stranded DNA oligonucleotide containing 3'-phosphotyrosine as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed