BDBM50425026 CHEMBL241898

SMILES Oc1c(cc([N+]([O-])=O)c2cccnc12)[N+]([O-])=O

InChI Key InChIKey=YPEUTQKEMPFPKO-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50425026   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50425026(CHEMBL241898)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli EC538 assessed as reduction in N-formylkynurenine formation using L-tryptophan as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50425026(CHEMBL241898)
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptopha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50425026(CHEMBL241898)
Affinity DataKi:  7.20E+4nMAssay Description:Uncompetitive inhibition of human recombinant cathepsin B endopeptidase activity using Z-Arg-Arg-AMC substrate assessed as inhibition constant for en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50425026(CHEMBL241898)
Affinity DataKi:  1.46E+5nMAssay Description:Noncompetitive inhibition of human recombinant cathepsin B exopeptidase activity using Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed