BDBM50424958 CHEMBL2316157::US9409845, Table 1, Compound 18: (2E,6E)-2,6-(3,5-dimethoxybenzylidene)-6-(3,5-dimethoxybenzylidene)cyclohexanone

SMILES COc1cc(OC)cc(\C=C2/CCC\C(=C/c3cc(OC)cc(OC)c3)C2=O)c1

InChI Key InChIKey=LCTMHSXNDBNPAF-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50424958   

TargetEpidermal growth factor receptor(Human)
Pharmaxyn Laboratories

US Patent
LigandPNGBDBM50424958(CHEMBL2316157 | US9409845, Table 1, Compound 18: (...)
Affinity DataIC50: 2.08E+3nMT: 2°CAssay Description:The kinase activity of EGFR was detected according to time-resolved fluorescence detection technology to evaluate automatic phosphorylation levels. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
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TargetEpidermal growth factor receptor(Human)
Pharmaxyn Laboratories

US Patent
LigandPNGBDBM50424958(CHEMBL2316157 | US9409845, Table 1, Compound 18: (...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR cytoplasmic domain (amino acids 645 to 1186) (unknown origin) expressed in Sf9 cells assessed as reduction in enzyme autophosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM50424958(CHEMBL2316157 | US9409845, Table 1, Compound 18: (...)
Affinity DataEC50:  5.30E+3nMAssay Description:Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed