BDBM50424783 CHEMBL2315104

SMILES FC(F)(F)c1ccccc1C(=O)N1CCN(CC1)c1ccc(nn1)C(=O)NCc1ccccc1

InChI Key InChIKey=CKIBNNYWZAXTRH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50424783   

TargetStearoyl-CoA desaturase(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424783(CHEMBL2315104)
Affinity DataIC50: 41nMAssay Description:Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAcyl-CoA desaturase 1(Mouse)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424783(CHEMBL2315104)
Affinity DataIC50: 6nMAssay Description:Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetdCTP pyrophosphatase 1(Human)
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50424783(CHEMBL2315104)
Affinity DataIC50: 240nMAssay Description:Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details Article
PubMed
TargetStearoyl-CoA desaturase(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424783(CHEMBL2315104)
Affinity DataIC50: 750nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as ratio of cellular protein product over substrate after 72 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details Article
PubMed