BDBM50424538 CHEMBL2312140

SMILES COc1cc(Nc2ncc(Cl)c(n2)-c2cccc(CC#N)c2)ccc1N1CCN(C)CC1

InChI Key InChIKey=ZLZJYPLAARWUEF-UHFFFAOYSA-N

Data  3 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50424538   

TargetSerine/threonine-protein kinase PAK 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424538(CHEMBL2312140)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424538(CHEMBL2312140)
Affinity DataEC50:  4.73E+3nMAssay Description:Inhibition of PAK1 in human OVCAR3 cells assessed as MEK phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424538(CHEMBL2312140)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of TNIK-mediated TCF4/beta-casein transcription in human HCT116 cells by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424538(CHEMBL2312140)
Affinity DataKd:  86nMAssay Description:Competitive binding affinity to TNIK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50424538(CHEMBL2312140)
Affinity DataIC50: 65nMAssay Description:Inhibition of TNIK (unknown origin) by ADP glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed