BDBM50424344 CHEMBL2314779

SMILES OCC(NCc1ccccc1)c1ccc(C(=O)c2ccccc2)c(NC(=O)[C@@H](NC(=O)OCc2ccccc2)c2ccccc2)c1

InChI Key InChIKey=LKLJXPROGULUMH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50424344   

TargetBeta-secretase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50424344(CHEMBL2314779)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human recombinant BACE-1 using acetyl-C(W8044-Eu)-EVNLDAEFK-QSY7 as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50424344(CHEMBL2314779)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing modified BACE cleavage sequence of APP, NFEV and K612V mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50424344(CHEMBL2314779)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of BACE1 in human SHSY5Y cells expressing APP NFEV and wild-type alpha-cleavage siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed