BDBM50424075 (-)-Corydalmine::CHEMBL448891

SMILES COc1cc2CCN3Cc4c(C[C@H]3c2cc1OC)ccc(O)c4OC

InChI Key InChIKey=DIHXHTWYVOYYDC-UHFFFAOYSA-N

Data  8 KI  8 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50424075   

TargetTissue factor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 152nMAssay Description:Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 1.87E+4nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 2.13E+4nMAssay Description:Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataEC50:  1.35E+3nMAssay Description:Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataEC50:  190nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation prox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Tianjin University of Technology

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of amyloid beta 42 (unknown origin) aggregation incubated for 24 hrs by ThT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCholinesterase(Human)
Tianjin University of Technology

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 1.24E+5nMAssay Description:Inhibition of BChE (unknown origin) using BTCI as substrate preincubated for 15 min followed by substrate addition measured after 40 min by Ellman's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Tianjin University of Technology

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 2.11E+5nMAssay Description:Inhibition of AChE (unknown origin) using ATCI as substrate preincubated for 15 min followed by substrate addition measured after 40 min by Ellman's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi:  107nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi:  149nMAssay Description:Displacement of [3H]8-OH-DPAT from 5-HT1A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi:  242nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi:  305nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi:  533nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D4 receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50424075((-)-Corydalmine | CHEMBL448891)
Affinity DataKi:  1.71E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed