BDBM50421183 CHEMBL2086789

SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)N(CCOc1ccc2ccccc2c1)S(=O)(=O)c1ccc(NO)cc1

InChI Key InChIKey=KVPUAIYIBNDBLI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50421183   

TargetGTPase NRas(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50421183(CHEMBL2086789)
Affinity DataIC50: 500nMAssay Description:Inhibition of N-Ras expressed in Escherichia coli using [3H]GDP and [3H]GTP assessed as inhibition of intrinsic nucleotide exchange by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50421183(CHEMBL2086789)
Affinity DataIC50: 700nMAssay Description:Binding affinity to GDP-bound KRAS G12V RAS mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed