BDBM50420797 CHEMBL2030281

SMILES Oc1c(Sc2nnc[nH]2)cc(NS(=O)(=O)c2ccc3ccccc3c2)c2ccccc12

InChI Key InChIKey=UGODIOOKONOGOI-UHFFFAOYSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50420797   

TargetHistone acetyltransferase GCN5(Baker's yeast)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50420797(CHEMBL2030281)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase GCN5(Baker's yeast)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50420797(CHEMBL2030281)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase GCN5(Baker's yeast)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50420797(CHEMBL2030281)
Affinity DataIC50: 670nMAssay Description:Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50420797(CHEMBL2030281)
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase GCN5(Baker's yeast)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50420797(CHEMBL2030281)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50420797(CHEMBL2030281)
Affinity DataIC50: 400nMAssay Description:Inhibition of human 6x-His tagged wild type BRAF expressed in Sf9 cells by ELISA based kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50420797(CHEMBL2030281)
Affinity DataKd:  3.60E+3nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed